David B. Reath, MD
Knoxville, TN (865) 450-9253

Our Game-Changing SkinPen Procedure: Yay! No Blood Required. Part 2

A better way to get your growth factors.

I left off Part 1 of my last (vampirish) article with the question of whether there was an easier way to acquire and use growth factors for microneedling than drawing blood and using Platelet Rich Plasma (PRP).

Could we find a product with a consistent yield of the growth factors that we want to help with healing and anti-aging instead? In a word, yes.

Enter AnteAGE 

What AnteAGE allows us to do is bypass the acquisition of Platelet Rich Plasma (PRP) for their content of growth factors and go directly to the growth factors themselves.

In essence, we are omitting the intermediary step to get to the next level of skin care technology. It’s sort of like developing countries who implement their telephone communication systems by bypassing landlines and going directly to cell phones.

It starts in the bones, not in the blood.


Several different types of cells produce growth factors (GF’s). Research has shown that some of the most important cells for this are bone marrow derived mesenchymal stem cells (BM-MSC). These cells are able to differentiate into many different cell lines and are the cells that are primarily used for tissue regeneration. And, they are the best cells at producing GF’s, compared to platelets, fibroblasts, or adipocytes (fat cells).

But there’s more to it than that.

Different growth factors do different things. Their effect on inflammation is key. Some GF’s promote inflammation and are “pro-inflammatory,” and others reduce inflammation, “anti-inflammatory.” While inflammation is a key element of wound healing, it can be detrimental to tissues in terms of aging, especially if it happens over and over again. This is referred to as chronic inflammation.

What is best for anti-aging and wound healing are the anti-inflammatory GF’s and these come from the bone marrow as opposed to the platelet derived growth factors from PRP which contain pro-inflammatory GF’s.

AnteAGE MD Stem | GF & Cytokines


While we were researching what to do with the whole PRP issue, we discovered AnteAGE MD. These products contain the anti-inflammatory growth factors and cytokine signaling molecules which are derived and cultured from pristine human bone marrow, BM-MSC’s.  They’re pre-packaged and require no blood drawing in the office (Sorry, Dracula).

So, patients get the boost they’re looking for without inflammation, especially important for those who have irritation from some skin care products. Their daily use products are great and at the very least on par with our TNS Serum from SkinMedica. But that’s not the best part.

You could call it a “Growth Factor Facial”

The AnteAGE MD MicroNeedling Solution is the real game-changer. When we originally started looking at PRP what we really wanted were growth factors that we could use with our SkinPen procedures. This solution gives us exactly what we are looking for: an easily obtained, consistent product of anti-inflammatory GF’s individually packaged with a roller ball specifically for microneedling. It also contains Hyaluronic acid and recombinant Transforming Growth Factor Beta 3 which really tamps the inflammation. It’s a total home run for patients.
AnteAGE MD vs. PRP

AnteAGE MD Growth Factors PRP
Requires blood draw, and waiting time for centrifuge No Yes
Quantitative amount of growth factors We know exactly what we’re putting into the skin. Impossible to know.
Results A real “wow” factor. Same as microneedling without it.
Inflammation factor Anti-inflammatory Highly pro-inflammatory
Product consistency and application Roller ball gel suspension designed for microneedling  Runny and messy
Cost Included in the package price $300

So, if you are up for a real treat, have a Growth Factor Facial, or GFF. It will definitely be your BFF. Buffy agrees.

All-in with Growth Factors.


If there is one thing that really has caught our attention in the last year, it’s growth factors. They, without a doubt, are for real and make a noticeable difference. The PRP facial may very well be snake oil, a common phenomenon in the world of aesthetics and plastic surgery, but we can assure you that growth factors are here to stay. Indeed, it will be exciting to see how growth factors continue to be developed and used. For now, we are loving our AnteAGE and so will you.

All the best,

Dr David B. Reath blog signature



David B. Reath, MD
PS: Here is a link to part 1 of this series:

Shining Light on “Vampire” PRP Skin Care Procedures. Part 1

Lately there has been a lot of discussion about platelet rich plasma, or PRP. It’s being used mainly in orthopedics and sports medicine to boost healing in bone grafts and fractures. So naturally, people in the world of aesthetics are jumping on the bandwagon. Where the vampires come in. Microneedling with PRP (platelet rich plasma) … Read more »

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6 Responses to Our Game-Changing SkinPen Procedure: Yay! No Blood Required. Part 2

  • Kris Price says:

    When comparing my first SkinPen without the AnteAge with my 2nd SkinPen treatment last week, I believe the AnteAge products made a difference in my healing process. I was red for almost THREE days the first time and my redness was almost totally gone within 6 hours the 2nd time! I also didn’t peel as much the 2nd time. Finally, my 2nd treatment was less painful – not sure if it was because I’d already been through it once or that the GF serum used during the procedure didn’t bother me as much. Can’t wait for my 3rd and final treatment!

  • David B Reath, MD says:

    Dear Kris,
    We are so glad you are liking the SkinPen with growth factors, our “growth factor facial”. Without a doubt, the AnteAge growth factors are a real game changer.
    All the best,
    David B. Reath, MD

  • Dawna says:

    Cultured from pristine human bone marrow? Why, that doesn’t sound creepy at all. Some strangers bone marrow donation that might or might not be hiv positve… sure, sign me right up…not! This sounds totally creepy 2 me.

    • Dr. Reath says:

      Dear Dawna,
      Thanks for your comment. This is a very common misunderstanding, so it’s good that you brought it up. From the scientists at AnteAge:

      “The stem cells are obtained from healthy and closely monitored volunteer donors under rigorous FDA oversight. The same cells are provided to hospitals and research labs. Any single paid, volunteer donor, at any reputable bone marrow donor bank, is only allowed to donate once they pass rigorous health screenings and are thoroughly tested for any diseases. So right off the bat you know there is zero disease in the marrow.

      The extracted marrow is then tested yet again to be sure it is free of disease. Once we get the stem cells from the marrow and begin culturing them in our lab, they release the proteins (GF’s, Cytokines, etc) that we filter out and use in the end product.

      Proteins are not whole, living cells and do not contain a nucleus. No nucleus means no ability to carry and transmit genetic material (disease) to a new host. So even in the completely unlikely situation that a marrow sample did have disease, the end product you use would never be able to carry that disease as only the proteins are contained within the bottle.”

  • Jennifer says:

    I absolutely LOVE my skin after the Skin Pen with Anteage Growth Factors! I was told I looked 10 years younger by a friend when she saw me a week after my second treatment. It softened my forehead wrinkles, made the crepey skin under my eyes thicken up, made my pores look smaller, and gave my skin a beautiful glow. I still can’t stop touching my smooth new face. I’d already been using Anteage Serum for 3 years or so and loved it. I wish I could win a lifetime supply of the SkiNPen Anteage treatments. I plan on splurging once a year on the three treatment package because it actually WORKS.

  • David B Reath says:

    Dear Jennifer,
    Thanks for your comments about Skin Pen with AnteAGE MD Growth Factors. This is an incredibly powerful skin rejuvenation combination. We are so sold on this that I joke that it’s worth selling one of your children for — just kidding here, on most days.
    But this is really the best skin care procedure we have. Your plan to have several SkinPens a year and use the AnteAGE on a daily basis, is a great plan. Keep it up and your skin will continue to look better and better.
    All the best,
    David B. Reath, MD

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